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sickle cell disease

Hertz Nazaire

Sickle cell disease (sickle cell anemia, sickle hemoglobin C disease, sickle hemoglobin D disease, sickle hemoglobin E disease, and sickle beta thalassemia) is a group of hereditary disorders that affect the red blood cells. Two genes for the sickle hemoglobin must be inherited from one's parents in order to have the disease. A person who receives a gene for sickle cell disease from one parent and a normal gene from the other has a condition called "sickle cell trait." Sickle cell trait produces no symptoms or problems for most people. Sickle cell disease can neither be contracted nor passed on to another person. The severity of sickle cell disease varies tremendously. Some people with sickle cell disease lead lives that are nearly normal. Others are less fortunate, and can suffer from a variety of complications. Sickle cell disease and other hemoglobinopathies are present in all population groups but are more prevalent in persons of African, Mediterranean, Asian, Southeast Asian, Caribbean, and South and Central American origins. In California, the incidence of sickle cell disease is about 1 per 4,400. more…


In partnership with the SCDAA, Cayenne Wellness Center and Children's Foundation supports patients signed-up in the Get Connected registry. If you are a patient with Sickle Cell Disease or Sickle Cell Trait, please call us at 818-940-0079 to receive guidance from our friendly staff who will help you complete the registration process over the phone, or visit www.GetConnectedSCD.org to complete your registration online. more…


Hydroxyurea is a medication that has been shown to reduce painful crisis, reduce hospitalizations, and may improve both the length and quality of life in patients with sickle cell disease. Hydroxyurea, also known by the brand names Hydrea or Droxia, was originally developed as chemotherapy, but later was shown to be effective at increasing the production of hemoglobin F(fetal) in red blood cells. Hemoglobin F interferes with the formation of stiff sickled cells, keeping red blood cells soft and flexible. more…


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